Cyclization of N-Terminal Glutamic Acid to pyro-Glutamic Acid Impacts Monoclonal Antibody Charge Heterogeneity Despite Its Appearance as a Neutral Transformation.

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第一作者： Zhihua,Liu

第一单位： Drug Product Science & Technology, Bristol-Myers Squibb Company, 1 Squibb Drive, New Brunswick, New Jersey 08903. Electronic address: Zhihua.Liu@bms.com.

作者： Zhihua,Liu ^[1] ; Joseph,Valente ^[2] ; Shujie,Lin ^[2] ; Naresh,Chennamsetty ^[2] ; Difei,Qiu ^[2] ; Mark,Bolgar ^[2]

作者单位： Drug Product Science & Technology, Bristol-Myers Squibb Company, 1 Squibb Drive, New Brunswick, New Jersey 08903. Electronic address: Zhihua.Liu@bms.com. ^[1] Drug Product Science & Technology, Bristol-Myers Squibb Company, 1 Squibb Drive, New Brunswick, New Jersey 08903. ^[2]

关键词 charge variant isoelectric focusing monoclonal antibody pyroglutamic acid

主题词抗体, 单克隆(Antibodies, Monoclonal);环化(Cyclization);谷氨酸(Glutamic Acid);谷氨酰胺(Glutamine);吡咯烷酮羧酸(Pyrrolidonecarboxylic Acid)

DOI 10.1016/j.xphs.2019.05.023

PMID 31145921

发布时间 2020-08-19

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