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首页> Cancer> Universal endometrial cancer tumor typing: How much has immunohistochemistry, microsatellite instability, and MLH1 methylation improved the diagnosis of Lynch syndrome across the population?

Universal endometrial cancer tumor typing: How much has immunohistochemistry, microsatellite instability, and MLH1 methylation improved the diagnosis of Lynch syndrome across the population?

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第一作者： Ryan M,Kahn

第一单位： Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, New York.

作者： Ryan M,Kahn ^[1] ; Sushmita,Gordhandas ^[1] ; Brandon Paul,Maddy ^[1] ; Becky,Baltich Nelson ^[2] ; Gulce,Askin ^[3] ; Paul J,Christos ^[3] ; Thomas A,Caputo ^[4] ; Eloise,Chapman-Davis ^[4] ; Kevin,Holcomb ^[4] ; Melissa K,Frey ^[4]

作者单位： Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, New York. ^[1] Department of Information Technologies and Services, Weill Cornell Medical College, New York, New York. ^[2] Clinical and Translational Science Center, Department of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, New York. ^[3] Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, New York. ^[4]

关键词 Lynch syndrome endometrial cancer gynecologic oncology immunohistochemistry microsatellite instability mutL homolog 1 (MLH1) methylation

主题词癌, 子宫内膜样(Carcinoma, Endometrioid);DNA甲基化(DNA Methylation);DNA错配修复(DNA Mismatch Repair);DNA结合蛋白质类(DNA-Binding Proteins);子宫内膜肿瘤(Endometrial Neoplasms);女(雌)性(Female);人类(Humans);免疫组织化学(Immunohistochemistry);Lynch综合征Ⅱ型(Lynch Syndrome II);微卫星不稳定性(Microsatellite Instability);中年人(Middle Aged);分子诊断技术(Molecular Diagnostic Techniques);MutS同源蛋白2(MutS Homolog 2 Protein);肿瘤, 囊性, 黏液性和浆液性(Neoplasms, Cystic, Mucinous, and Serous)

DOI 10.1002/cncr.32203

PMID 31150123

发布时间 2020-05-21

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Cancer

Cancer

2019年125卷18期

3172-3183页

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