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Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study.

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作者: Meng,Zhu [1] ; Kuanfeng,Xu [2] ; Yang,Chen [3] ; Yong,Gu [1] ; Mei,Zhang [1] ; Feihong,Luo [1] ; Yu,Liu [1] ; Wei,Gu [4] ; Ji,Hu [5] ; Haixia,Xu [6] ; Zhiguo,Xie [7] ; Chengjun,Sun [8] ; Yuxiu,Li [9] ; Min,Sun [10] ; Xinyu,Xu [11] ; Hsiang-Ting,Hsu [4] ; Heng,Chen [12] ; Qi,Fu [1] ; Yun,Shi [1] ; Jingjing,Xu [1] ; Li,Ji [1] ; Jin,Liu [1] ; Lingling,Bian [1] ; Jing,Zhu [1] ; Shuang,Chen [1] ; Lei,Xiao [1] ; Xin,Li [1] ; Hemin,Jiang [1] ; Min,Shen [1] ; Qianwen,Huang [1] ; Chen,Fang [1] ; Xia,Li [1] ; Gan,Huang [1] ; Jingyi,Fan [8] ; Zhu,Jiang [7] ; Yue,Jiang [9] ; Juncheng,Dai [10] ; Hongxia,Ma [11] ; Shuai,Zheng [9] ; Yun,Cai [10] ; Hao,Dai [11] ; Xuqin,Zheng [2] ; Hongwen,Zhou [2] ; Shining,Ni [2] ; Guangfu,Jin [2] ; Jin-Xiong,She [2] ; Liping,Yu [1] ; Constantin,Polychronakos [1] ; Zhibin,Hu [1] ; Zhiguang,Zhou [1] ; Jianping,Weng [1] ; Hongbing,Shen [6] ; Tao,Yang [2]
作者单位: Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [1] State Key Laboratory of Reproductive Medicine, Center for Global Health, Nanjing Medical University, Nanjing, China. [2] Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China. [3] Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, Shanghai, China. [4] Department of Endocrinology and Metabolism, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China. [5] Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China. [6] Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Soochow University, Suzhou, China. [7] Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. [8] Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China. [9] National Clinical Research Center for Metabolic Diseases, Changsha, China. [10] Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, Changsha, China. [11] Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. [12] Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA. [13] Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO. [14] The Endocrine Genetics Laboratory, Child Health and Human Development Program and Department of Pediatrics, McGill University Health Centre Research Institute, Montreal, Canada. [15] State Key Laboratory of Reproductive Medicine, Center for Global Health, Nanjing Medical University, Nanjing, China yangt@njmu.edu.cn hbshen@njmu.edu.cn wjianp@mail.sysu.edu.cn zhouzhiguang@csu.edu.cn zhibin_hu@njmu.edu.cn. [16] Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China yangt@njmu.edu.cn hbshen@njmu.edu.cn wjianp@mail.sysu.edu.cn zhouzhiguang@csu.edu.cn zhibin_hu@njmu.edu.cn. [17] Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China yangt@njmu.edu.cn hbshen@njmu.edu.cn wjianp@mail.sysu.edu.cn zhouzhiguang@csu.edu.cn zhibin_hu@njmu.edu.cn. [18] Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China yangt@njmu.edu.cn hbshen@njmu.edu.cn wjianp@mail.sysu.edu.cn zhouzhiguang@csu.edu.cn zhibin_hu@njmu.edu.cn. [19] Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, China. [20]
DOI 10.2337/dc18-2023
PMID 31152121
发布时间 2022-12-07
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