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首页> Proceedings of the National Academy of Sciences of the United States of America> A major role for noncoding regulatory mutations in the evolution of enzyme activity.

A major role for noncoding regulatory mutations in the evolution of enzyme activity.

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作者： David W,Loehlin ^[1] ; Jesse R,Ames ^[2] ; Kathy,Vaccaro ^[3] ; Sean B,Carroll ^[4]

作者单位： Biology Department, Williams College, Williamstown, MA 01267; dwl1@williams.edu carrolls@hhmi.org. ^[1] Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI 53705. ^[2] Laboratory of Cell and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53705. ^[3] Biology Department, Williams College, Williamstown, MA 01267. ^[4] Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53705. ^[5] Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI 53705; dwl1@williams.edu carrolls@hhmi.org. ^[6] Howard Hughes Medical Institute, University of Maryland, College Park, MD 20742-5815. ^[7] Department of Biology, University of Maryland, College Park, MD 20742-5815. ^[8]

关键词 Drosophila alcohol dehydrogenase enzyme evolution regulatory

主题词醇脱氢酶(Alcohol Dehydrogenase);氨基酸取代(Amino Acid Substitution);动物(Animals);生物进化(Biological Evolution);果蝇属(Drosophila);模型, 生物学(Models, Biological);突变(Mutation);种特异性(Species Specificity)

DOI 10.1073/pnas.1904071116

PMID 31152141

发布时间 2020-04-08

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

2019年116卷25期

12383-12389页

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Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

2019年116卷25期

12383-12389页

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