Adiponectin inhibits proliferation of vascular endothelial cells induced by Ox-LDL by promoting dephosphorylation of Caveolin-1 and depolymerization of eNOS and up-regulating release of NO.
作者:
主题词
脂联素(Adiponectin);主动脉(Aorta);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);窖蛋白1(Caveolin 1);细胞系(Cell Line);细胞增殖(Cell Proliferation);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);内皮细胞(Endothelial Cells);人类(Humans);脂蛋白类, LDL(Lipoproteins, LDL);一氧化氮(Nitric Oxide);一氧化氮合酶Ⅲ型(Nitric Oxide Synthase Type III);磷酰化(Phosphorylation);增量调节(Up-Regulation)
DOI
10.1016/j.intimp.2019.05.017
PMID
31152980
发布时间
2019-12-27
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International immunopharmacology
424-434页
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