Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA.

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作者： Xiao-Juan,Yang ^[1] ; Hong,Zhu ^[2] ; Shi-Rong,Mu ^[2] ; Wen-Juan,Wei ^[2] ; Xun,Yuan ^[3] ; Meng,Wang ^[2] ; Yanchao,Liu ^[3] ; Jingyi,Hui ^[4] ; Ying,Huang ^[5]

作者单位： CAS Center for Excellence in Molecular Cell Science, Shanghai 200031, China,; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China, and; Shanghai Key Laboratory of Molecular Andrology, Shanghai 200031, China. ^[1] CAS Center for Excellence in Molecular Cell Science, Shanghai 200031, China,; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China, and. ^[2] State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China, and; Shanghai Key Laboratory of Molecular Andrology, Shanghai 200031, China. ^[3] CAS Center for Excellence in Molecular Cell Science, Shanghai 200031, China,; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China, and. Electronic address: jyhui@sibcb.ac.cn. ^[4] State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China, and; Shanghai Key Laboratory of Molecular Andrology, Shanghai 200031, China. Electronic address: huangy@sibcb.ac.cn. ^[5]

关键词 Y-box binding protein 1 (YB-1)cancer cold shock domain (CSD)crystal structure gene expression oncogene post-transcriptional regulation single-stranded RNA binding splicing regulation structural biology