5-Lipoxagenase deficiency attenuates L-NAME-induced hypertension and vascular remodeling.

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第一作者： Jia-Xiang,Chen

第一单位： Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.

作者： Jia-Xiang,Chen ^[1] ; Kun-Yue,Xue ^[1] ; Juan-Juan,Xin ^[1] ; Xin,Yan ^[2] ; Ru-Li,Li ^[1] ; Xiao-Xiao,Wang ^[1] ; Xu-Lei,Wang ^[3] ; Ming-Ming,Tong ^[1] ; Lu,Gan ^[1] ; He,Li ^[1] ; Jie,Lan ^[1] ; Xue,Li ^[1] ; Cai-Li,Zhuo ^[1] ; Ling-Yu,Li ^[1] ; Zi-Jie,Deng ^[1] ; Heng-Yu,Zhang ^[4] ; Wei,Jiang ^[5]

作者单位： Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. ^[1] Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. ^[2] Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; School of Life Sciences and Bioengineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, PR China. ^[3] Department of Cardiology, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China. ^[4] Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address: wcumsjw@scu.edu.cn. ^[5]

关键词 5-lipoxygenase Cysteinyl leukotriene Hypertension Leukotriene B4 Vascular remodeling

主题词动物(Animals);主动脉(Aorta);花生四烯酸盐5-脂氧合酶(Arachidonate 5-Lipoxygenase);血压(Blood Pressure);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);高血压(Hypertension);白三烯A4(Leukotriene A4);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);肌, 平滑, 血管(Muscle, Smooth, Vascular);NG-硝基精氨酸甲酯(NG-Nitroarginine Methyl Ester);中性白细胞(Neutrophils);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley)

DOI 10.1016/j.bbadis.2019.05.021

PMID 31167124

发布时间 2020-05-07

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Biochimica et biophysica acta. Molecular basis of disease

2019年1865卷9期

2379-2392页

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5-Lipoxagenase deficiency attenuates L-NAME-induced hypertension and vascular remodeling.

Biochimica et biophysica acta. Molecular basis of disease

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Biochimica et biophysica acta. Molecular basis of disease

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5-Lipoxagenase deficiency attenuates L-NAME-induced hypertension and vascular remodeling.

Biochimica et biophysica acta. Molecular basis of disease

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Biochimica et biophysica acta. Molecular basis of disease

相关期刊

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