Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.

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作者： Christian B,Lessard ^[1] ; Edgardo,Rodriguez ^[2] ; Thomas B,Ladd ^[1] ; Lisa M,Minter ^[3] ; Barbara A,Osborne ^[3] ; Lucio,Miele ^[4] ; Todd E,Golde ^[5] ; Yong,Ran ^[6]

作者单位： Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida 32610. ^[1] Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610. ^[2] Department of Veterinary and Animal Sciences, Center for Bioactive Delivery, Institute for Applied Life Sciences, and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Massachusetts 01003. ^[3] Department of Genetics and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112. ^[4] Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida 32610 tgolde@ufl.edu. ^[5] Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida 32610 yran@ufl.edu. ^[6]

关键词 NOTCH Notch protein amyloid protein precursor amyloid-beta (AB)aspartyl protease cancer inhibitor neurodegeneration presenilin γ-secretase