NCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-κB/miR-188-3p pathways.

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作者： Fanzheng,Meng ^[1] ; Shugeng,Zhang ^[1] ; Ruipeng,Song ^[2] ; Yao,Liu ^[1] ; Jiabei,Wang ^[2] ; Yingjian,Liang ^[1] ; Jizhou,Wang ^[2] ; Jihua,Han ^[3] ; Xuan,Song ^[1] ; Zhaoyang,Lu ^[1] ; Guangchao,Yang ^[1] ; Shangha,Pan ^[4] ; Xianying,Li ^[1] ; Yufeng,Liu ^[1] ; Fang,Zhou ^[1] ; Yan,Wang ^[1] ; Yifeng,Cui ^[1] ; Bo,Zhang ^[1] ; Kun,Ma ^[1] ; Congyi,Zhang ^[1] ; Yufei,Sun ^[1] ; Mengyang,Xin ^[1] ; Lianxin,Liu ^[5]

作者单位： Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, China. ^[1] Department of General Surgery, Division of Life sciences and Medicine, The first Affiliated Hospital of University of Science and Technology, China. ^[2] Department of Head and Neck Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. ^[3] Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, China. ^[4] Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: liulianxin@ems.hrbmu.edu.cn. ^[5]

关键词 Hepatocellular carcinoma NCAPG2 NF-κB STAT3 miR-188-3p

主题词动物(Animals);结合部位(Binding Sites);癌, 肝细胞(Carcinoma, Hepatocellular);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);染色体蛋白质类, 非组蛋白(Chromosomal Proteins, Non-Histone);疾病模型, 动物(Disease Models, Animal);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);肝肿瘤(Liver Neoplasms);小鼠(Mice);微RNAs(MicroRNAs);模型, 生物学(Models, Biological);NF-κB(NF-kappa B);肿瘤转移(Neoplasm Metastasis);人口动力学(Population Dynamics);预后(Prognosis);启动区, 遗传(Promoter Regions, Genetic);蛋白质结合(Protein Binding);RNA干扰(RNA Interference);STAT3转录因子(STAT3 Transcription Factor);信号传导(Signal Transduction);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1016/j.ebiom.2019.05.053

PMID 31176678

发布时间 2021-04-26

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EBioMedicine

2019年44卷

237-249页

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NCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-κB/miR-188-3p pathways.

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NCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-κB/miR-188-3p pathways.

EBioMedicine

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