Enhanced penetration and cytotoxicity of metformin and collagenase conjugated gold nanoparticles in breast cancer spheroids.

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作者： Elaheh Dalir,Abdolahinia ^[1] ; Samad,Nadri ^[2] ; Reza,Rahbarghazi ^[3] ; Jaleh,Barar ^[4] ; Ayoub,Aghanejad ^[5] ; Yadollah,Omidi ^[6]

作者单位： Department of Medical Biotechnology, Zanjan University of Medical Sciences, Zanjan, Iran; Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran. ^[1] Department of Medical Nanotechnology, Zanjan University of Medical Sciences, Zanjan, Iran. Electronic address: nadri_s@zums.ac.ir. ^[2] Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. ^[3] Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. ^[4] Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran. ^[5] Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yomidi@tbzmed.ac.ir. ^[6]

关键词 Cancer stem cells Collagenase Gold nanoparticles Mammospheres Metformin Nanomedicine