In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes.

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第一作者： Shunsuke,Kawai

第一单位： Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.

作者： Shunsuke,Kawai ^[1] ; Hiroyuki,Yoshitomi ^[2] ; Junko,Sunaga ^[3] ; Cantas,Alev ^[1] ; Sanae,Nagata ^[2] ; Megumi,Nishio ^[3] ; Masataka,Hada ^[4] ; Yuko,Koyama ^[1] ; Maya,Uemura ^[1] ; Kazuya,Sekiguchi ^[3] ; Hirotsugu,Maekawa ^[3] ; Makoto,Ikeya ^[3] ; Sakura,Tamaki ^[1] ; Yonghui,Jin ^[1] ; Yuki,Harada ^[2] ; Kenichi,Fukiage ^[1] ; Taiji,Adachi ^[2] ; Shuichi,Matsuda ^[5] ; Junya,Toguchida ^[1]

作者单位： Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan. ^[1] Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. ^[2] Department of Regeneration Sciences and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan. ^[3] Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan. ^[4] Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan. ^[5] Institute for Advancement of Clinical and Translational Sciences, Kyoto University Hospital, Kyoto University, Kyoto, Japan. ^[6] Department of Pediatric Orthopaedics, Shiga Medical Center for Children, Shiga, Japan. ^[7] Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan. togjun@cira.kyoto-u.ac.jp. ^[8] Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. togjun@cira.kyoto-u.ac.jp. ^[9] Department of Regeneration Sciences and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan. togjun@cira.kyoto-u.ac.jp. ^[10] Institute for Advancement of Clinical and Translational Sciences, Kyoto University Hospital, Kyoto University, Kyoto, Japan. togjun@cira.kyoto-u.ac.jp. ^[11]

主题词动物(Animals);骨形态发生蛋白质类(Bone Morphogenetic Proteins);骨和骨组织(Bone and Bones);细胞分化(Cell Differentiation);细胞, 培养的(Cells, Cultured);基因表达调控(Gene Expression Regulation);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);男(雄)性(Male);小鼠(Mice);小鼠, 裸(Mice, Nude);小鼠, SCID(Mice, SCID);突变(Mutation);骨生成(Osteogenesis);表型(Phenotype);受体, 维甲酸(Receptors, Retinoic Acid);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);移植(Transplantation);维甲酸(Tretinoin)

DOI 10.1038/s41551-019-0410-7

PMID 31182836

发布时间 2021-12-04

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Nature biomedical engineering

2019年3卷7期

558-570页

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In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes.

Nature biomedical engineering

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In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes.

Nature biomedical engineering

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Nature biomedical engineering

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