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Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy.

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第一作者： Fan,Yang

第一单位： Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

作者： Fan,Yang ^[1] ; Ying,Qin ^[2] ; Yueqiu,Wang ^[1] ; Songyan,Meng ^[3] ; Huimin,Xian ^[4] ; Hui,Che ^[5] ; Jie,Lv ^[1] ; Yang,Li ^[1] ; Yahan,Yu ^[6] ; Yunlong,Bai ^[7] ; Lihong,Wang ^[5]

作者单位： Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. ^[1] Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China. ^[2] Department of Geriatrics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. ^[3] Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. ^[4] Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.;Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China. ^[5] Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China. ^[6] Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China.;Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China. ^[7]

关键词 AMPK NLRP3 inflammasome autophagy diabetic cardiomyopathy metformin