Effects of 17β-HSD2 inhibition in bones on osteoporosis based on an animal rat model.

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作者： Sebastian T,Müller ^[1] ; Sophie,Pählig ^[2] ; Ahmed,Merabet ^[3] ; Ahmed S,Abdelsamie ^[4] ; Chris J,van Koppen ^[5] ; Sandrine,Marchais-Oberwinkler ^[6] ; Rolf W,Hartmann ^[7] ; Oliver,Zierau ^[8] ; Günter,Vollmer ^[9]

作者单位： Technische Universität Dresden, Molecular Cell Physiology and Endocrinology, Institute for Zoology, Dresden, Germany. Electronic address: sebastian.mueller5@tu-dresden.de. ^[1] Technische Universität Dresden, Molecular Cell Physiology and Endocrinology, Institute for Zoology, Dresden, Germany. Electronic address: sophie.paehlig@web.de. ^[2] Institute for Pharmaceutical Chemistry, Philipps University Marburg, 35032, Marburg, Germany; Pharmaceutical and Medicinal Chemistry, Saarland University, Campus E8.1, 66123, Saarbrücken, Germany. Electronic address: ahmed.merabet@pharmazie.uni-marburg.de. ^[3] Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research, Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany; Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki, 12622, Cairo, Egypt. Electronic address: Ahmed-Saad-Abdelsamie.Ahmed@helmholtz-hzi.de. ^[4] Pharmaceutical and Medicinal Chemistry, Saarland University, Campus E8.1, 66123, Saarbrücken, Germany; Elexopharm GmbH, 66123, Saarbrücken, Germany. Electronic address: vankoppen@elexopharm.de. ^[5] Institute for Pharmaceutical Chemistry, Philipps University Marburg, 35032, Marburg, Germany. Electronic address: marchais@uni-marburg.de. ^[6] Pharmaceutical and Medicinal Chemistry, Saarland University, Campus E8.1, 66123, Saarbrücken, Germany; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research, Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany. Electronic address: Rolf.Hartmann@helmholtz-hzi.de. ^[7] Technische Universität Dresden, Molecular Cell Physiology and Endocrinology, Institute for Zoology, Dresden, Germany. Electronic address: oliver.zierau@tu-dresden.de. ^[8] Technische Universität Dresden, Molecular Cell Physiology and Endocrinology, Institute for Zoology, Dresden, Germany. Electronic address: guenter.vollmer@tu-dresden.de. ^[9]

关键词 17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2)Bone Hormone replacement therapy (HRT)Osteoporosis Ovariectomy-induced bone loss