Redox-Responsive and Dual-Targeting Hyaluronic Acid-Methotrexate Prodrug Self-Assembling Nanoparticles for Enhancing Intracellular Drug Self-Delivery.-论文-万方医学网

作者： Yubin,Zhang ^[1] ; Yang,Li ^[2] ; Haina,Tian ^[3] ; Qixin,Zhu ^[3] ; Fanfan,Wang ^[4] ; Zhongxiong,Fan ; Song,Zhou ; Xiaowen,Wang ; Liya,Xie ; Zhenqing,Hou

作者单位： CAS Key Laboratory of Design and Assembly of Functional Nanostructures, and Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter , Chinese Academy of Sciences , Fuzhou 350002 , China. ^[1] Department of Translational Medicine, Xiamen Institute of Rare Earth Materials , Chinese Academy of Sciences , Xiamen 361024 , P. R. China. ^[2] Department of General Surgery , The Affiliated Southeast Hospital of Xiamen University , Zhang Zhou 363000 , China. ^[3] The First Affiliated Hospital of Xiamen University , Xiamen 361002 , China. ^[4]

主题词动物(Animals);细胞存活(Cell Survival);二硫化物类(Disulfides);药物释放系统(Drug Delivery Systems);女(雌)性(Female);叶酸拮抗剂(Folic Acid Antagonists);人类(Humans);透明质酸(Hyaluronic Acid);甲氨蝶呤(Methotrexate);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);纳米粒子(Nanoparticles);氧化还原(Oxidation-Reduction);药物前体(Prodrugs);组织分布(Tissue Distribution);治疗结果(Treatment Outcome);肿瘤负荷(Tumor Burden);宫颈肿瘤(Uterine Cervical Neoplasms);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1021/acs.molpharmaceut.9b00359

PMID 31198046

发布时间 2020-06-08

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Redox-Responsive and Dual-Targeting Hyaluronic Acid-Methotrexate Prodrug Self-Assembling Nanoparticles for Enhancing Intracellular Drug Self-Delivery.

Molecular pharmaceutics

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Molecular pharmaceutics

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Redox-Responsive and Dual-Targeting Hyaluronic Acid-Methotrexate Prodrug Self-Assembling Nanoparticles for Enhancing Intracellular Drug Self-Delivery.

Molecular pharmaceutics

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Molecular pharmaceutics

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