Carvacrol encapsulated nanocarrier/ nanoemulsion abrogates angiogenesis by downregulating COX-2, VEGF and CD31 in vitro and in vivo in a lung adenocarcinoma model.

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作者： Imran,Khan ^[1] ; Monika,Bhardwaj ^[2] ; Shruti,Shukla ^[3] ; Hoomin,Lee ^[4] ; Mi-Hwa,Oh ^[5] ; Vivek K,Bajpai ^[6] ; Yun Suk,Huh ^[7] ; Sun Chul,Kang ^[8]

作者单位： Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, 100 Inha-ro, Nam-gu, Incheon, 22212, Republic of Korea; Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk, 38453, Republic of Korea. ^[1] Laboratory of Biochemistry and cellular Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, 42988, Republic of Korea; Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk, 38453, Republic of Korea. ^[2] Department of Energy and Materials Engineering, Dongguk University-Seoul, 30 Pildong-ro 1-gil, Seoul, 04620, Republic of Korea. ^[3] Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, 100 Inha-ro, Nam-gu, Incheon, 22212, Republic of Korea. ^[4] Animal Production Research and Development Division, National Institute of Animal Science, Jeonju, 54875, Republic of Korea. ^[5] Department of Energy and Materials Engineering, Dongguk University-Seoul, 30 Pildong-ro 1-gil, Seoul, 04620, Republic of Korea. Electronic address: vbajpai04@yahoo.com. ^[6] Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, 100 Inha-ro, Nam-gu, Incheon, 22212, Republic of Korea. Electronic address: yunsuk.huh@inha.ac.kr. ^[7] Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk, 38453, Republic of Korea. Electronic address: sckang@daegu.ac.kr. ^[8]

关键词 A549 Angiogenesis Carvacrol encapsulated nanoemulsion In silico In vivo