PRC2-Associated Chromatin Contacts in the Developing Limb Reveal a Possible Mechanism for the Atypical Role of PRC2 in HoxA Gene Expression.

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第一作者： Claudia,Gentile

第一单位： Genetics and Development Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada; Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, QC H4A 3J1, Canada.

作者： Claudia,Gentile ^[1] ; Soizik,Berlivet ^[2] ; Alexandre,Mayran ^[3] ; Denis,Paquette ^[4] ; Fanny,Guerard-Millet ^[5] ; Emmanuel,Bajon ^[4] ; Josée,Dostie ^[6] ; Marie,Kmita ^[7]

作者单位： Genetics and Development Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada; Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, QC H4A 3J1, Canada. ^[1] Genetics and Development Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada; Department of Biochemistry and Rosalind & Morris Goodman Cancer Research Center, McGill University, Montréal, QC H3G 1Y6, Canada. ^[2] Molecular Genetics Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada. ^[3] Department of Biochemistry and Rosalind & Morris Goodman Cancer Research Center, McGill University, Montréal, QC H3G 1Y6, Canada. ^[4] Genetics and Development Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada; Department of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada. ^[5] Department of Biochemistry and Rosalind & Morris Goodman Cancer Research Center, McGill University, Montréal, QC H3G 1Y6, Canada. Electronic address: josee.dostie@mcgill.ca. ^[6] Genetics and Development Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada; Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, QC H4A 3J1, Canada; Department of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada. Electronic address: marie.kmita@ircm.qc.ca. ^[7]

关键词 5C Hox genes PRC1 PRC2 TAD chromatin conformation enhancers gene regulation limb regulatory landscape