Development of a highly sensitive in vitro endothelial cell toxicity assay for evaluating ricin toxin A chain-based vaccines or therapeutics.

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第一作者： Nicholas J,Machesky

第一单位： Battelle Biomedical Research Center, 1425 Plain City Georgesville Road, West Jefferson, OH, 43162, USA.

作者： Nicholas J,Machesky ^[1] ; Janice M,Rusnak ^[2] ; Evan H,Moore ^[1] ; Christopher B,Dorsey ^[3] ; Lucy A,Ward ^[3]

作者单位： Battelle Biomedical Research Center, 1425 Plain City Georgesville Road, West Jefferson, OH, 43162, USA. ^[1] Medical Countermeasure Systems (MCS) Joint Vaccine Acquisition Program (JVAP), 1564 Freedman Drive, Fort Detrick, MD, 21702, USA. Electronic address: Janice.m.rusnak.ctr@mail.mil. ^[2] Medical Countermeasure Systems (MCS) Joint Vaccine Acquisition Program (JVAP), 1564 Freedman Drive, Fort Detrick, MD, 21702, USA. ^[3]

关键词 Endothelial cell toxicity assay Ricin Ricin toxin A chain Transendothelial electrical resistance Vaccine Vascular leak

主题词药物评价, 临床前(Drug Evaluation, Preclinical);电阻抗(Electric Impedance);内皮细胞(Endothelial Cells);人类(Humans);蓖麻蛋白(Ricin);毒性试验(Toxicity Tests)

DOI 10.1016/j.toxicon.2019.06.015

PMID 31207351

发布时间 2020-03-10

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