A chimeric poxvirus with J2R (thymidine kinase) deletion shows safety and anti-tumor activity in lung cancer models.
第一作者:
Shyambabu,Chaurasiya
第一单位:
Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
作者:
主题词
动物(Animals);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);女(雌)性(Female);基因缺失(Gene Deletion);基因, 报告(Genes, Reporter);绿色荧光蛋白质类(Green Fluorescent Proteins);人类(Humans);肺肿瘤(Lung Neoplasms);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);小鼠(Mice);溶瘤病毒疗法(Oncolytic Virotherapy);溶瘤病毒(Oncolytic Viruses);痘病毒科(Poxviridae);胸苷激酶(Thymidine Kinase);病毒蛋白质类(Viral Proteins);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1038/s41417-019-0114-x
PMID
31209267
发布时间
2021-12-24
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Cancer gene therapy
125-135页
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