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A small-molecule inhibitor of C5 complement protein.

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第一作者： Keith,Jendza

第一单位： Global Discovery Chemistry, Novartis Institutes of Biomedical Research, Cambridge, MA, USA.

作者： Keith,Jendza ^[1] ; Mitsunori,Kato ^[1] ; Michael,Salcius ^[2] ; Honnappa,Srinivas ^[3] ; Andrea,De Erkenez ^[4] ; Anh,Nguyen ^[4] ; Doug,McLaughlin ^[2] ; Celine,Be ^[3] ; Christian,Wiesmann ^[3] ; Jason,Murphy ^[2] ; Philippe,Bolduc ^[1] ; Muneto,Mogi ^[1] ; Jose,Duca ^[1] ; Abdel,Namil ^[1] ; Michael,Capparelli ^[1] ; Veronique,Darsigny ^[1] ; Erik,Meredith ^[1] ; Ritesh,Tichkule ^[1] ; Luciana,Ferrara ^[4] ; Jessica,Heyder ^[4] ; Fang,Liu ^[4] ; Patricia A,Horton ^[2] ; Michael J,Romanowski ^[2] ; Markus,Schirle ^[2] ; Nello,Mainolfi ^[1] ; Karen,Anderson ^[4] ; Gregory A,Michaud ^[5]

作者单位： Global Discovery Chemistry, Novartis Institutes of Biomedical Research, Cambridge, MA, USA. ^[1] Chemical Biology and Therapeutics, Novartis Institutes of Biomedical Research, Cambridge, MA, USA. ^[2] Chemical Biology and Therapeutics, Novartis Institutes of Biomedical Research, Basel, Switzerland. ^[3] Ophthalmology, Novartis Institutes of Biomedical Research, Cambridge, MA, USA. ^[4] Chemical Biology and Therapeutics, Novartis Institutes of Biomedical Research, Cambridge, MA, USA. gregory.michaud@novartis.com. ^[5]

医学主题词补体C5(Complement C5);人类(Humans);分子构象(Molecular Conformation);小分子化合物库(Small Molecule Libraries)

DOI 10.1038/s41589-019-0303-9

PMID 31209353

发布时间 2019-07-17

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