换一批Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers.
第一作者：
Frank,Qian
第一单位：
Department of Medicine, University of Chicago, Chicago, IL, USA.
作者：
Frank,Qian [1]
;
Matti A,Rookus [2]
;
Goska,Leslie [3]
;
Harvey A,Risch [4]
;
Mark H,Greene [5]
;
Cora M,Aalfs [6]
;
Muriel A,Adank [7]
;
Julian,Adlard [8]
;
Bjarni A,Agnarsson [9]
;
Munaza,Ahmed [10]
;
Kristiina,Aittomäki [11]
;
Irene L,Andrulis [12]
;
Norbert,Arnold [13]
;
Banu K,Arun [14]
;
Margreet G E M,Ausems [15]
;
Jacopo,Azzollini [16]
;
Daniel,Barrowdale [3]
;
Julian,Barwell [17]
;
Javier,Benitez [18]
;
Katarzyna,Białkowska [19]
;
Valérie,Bonadona [20]
;
Julika,Borde [21]
;
Ake,Borg [22]
;
Angela R,Bradbury [23]
;
Joan,Brunet [24]
;
Saundra S,Buys [25]
;
Trinidad,Caldés [26]
;
Maria A,Caligo [27]
;
Ian,Campbell [28]
;
Jonathan,Carter [29]
;
Jocelyne,Chiquette [30]
;
Wendy K,Chung [31]
;
Kathleen B M,Claes [32]
;
J Margriet,Collée [33]
;
Marie-Agnès,Collonge-Rame [34]
;
Fergus J,Couch [35]
;
Mary B,Daly [36]
;
Capucine,Delnatte [37]
;
Orland,Diez [38]
;
Susan M,Domchek [23]
;
Cecilia M,Dorfling [39]
;
Jacqueline,Eason [40]
;
Douglas F,Easton [41]
;
Ros,Eeles [42]
;
Christoph,Engel [43]
;
D Gareth,Evans [44]
;
Laurence,Faivre [45]
;
Lidia,Feliubadaló [46]
;
Lenka,Foretova [47]
;
Eitan,Friedman [48]
;
Debra,Frost [3]
;
Patricia A,Ganz [49]
;
Judy,Garber [50]
;
Vanesa,Garcia-Barberan [25]
;
Andrea,Gehrig [51]
;
Gord,Glendon [52]
;
Andrew K,Godwin [53]
;
Encarna B,Gómez Garcia [54]
;
Ute,Hamann [55]
;
Jan,Hauke [56]
;
John L,Hopper [57]
;
Peter J,Hulick [58]
;
Evgeny N,Imyanitov [59]
;
Claudine,Isaacs [60]
;
Louise,Izatt [61]
;
Anna,Jakubowska [62]
;
Ramunas,Janavicius [63]
;
Esther M,John [64]
;
Beth Y,Karlan [65]
;
Carolien M,Kets [66]
;
Yael,Laitman [67]
;
Conxi,Lázaro [46]
;
Dominique,Leroux [68]
;
Jenny,Lester [65]
;
Fabienne,Lesueur [69]
;
Jennifer T,Loud [5]
;
Jan,Lubiński [19]
;
Alicja,Łukomska [19]
;
Lesley,McGuffog [3]
;
Noura,Mebirouk [70]
;
Hanne E J,Meijers-Heijboer [71]
;
Alfons,Meindl [72]
;
Austin,Miller [73]
;
Marco,Montagna [74]
;
Thea M,Mooij [2]
;
Emmanuelle,Mouret-Fourme [75]
;
Katherine L,Nathanson [23]
;
Bita,Nehoray [76]
;
Susan L,Neuhausen [77]
;
Heli,Nevanlinna [78]
;
Finn C,Nielsen [79]
;
Kenneth,Offit [80]
;
Edith,Olah [81]
;
Kai-Ren,Ong [82]
;
Jan C,Oosterwijk [83]
;
Laura,Ottini [84]
;
Michael T,Parsons [85]
;
Paolo,Peterlongo [86]
;
Georg,Pfeiler [87]
;
Nisha,Pradhan [88]
;
Paolo,Radice [89]
;
Susan J,Ramus [90]
;
Johanna,Rantala [91]
;
Gad,Rennert [92]
;
Mark,Robson [93]
;
Gustavo C,Rodriguez [94]
;
Ritu,Salani [95]
;
Maren T,Scheuner [96]
;
Rita K,Schmutzler [97]
;
Payal D,Shah [23]
;
Lucy E,Side [98]
;
Jacques,Simard [99]
;
Christian F,Singer [87]
;
Doris,Steinemann [100]
;
Dominique,Stoppa-Lyonnet [101]
;
Yen Yen,Tan [87]
;
Manuel R,Teixeira [102]
;
Mary Beth,Terry [103]
;
Mads,Thomassen [104]
;
Marc,Tischkowitz [105]
;
Silvia,Tognazzo [74]
;
Amanda E,Toland [106]
;
Nadine,Tung [107]
;
Christi J,van Asperen [108]
;
Klaartje,van Engelen [109]
;
Elizabeth J,van Rensburg [39]
;
Laurence,Venat-Bouvet [110]
;
Jeroen,Vierstraete [32]
;
Gabriel,Wagner [87]
;
Lisa,Walker [111]
;
Jeffrey N,Weitzel [76]
;
Drakoulis,Yannoukakos [112]
;
KConFab Investigators [3]
;
HEBON Investigators [113]
;
GEMO Study Collaborators [114]
;
EMBRACE Collaborators [85]
;
Antonis C,Antoniou [115]
;
David E,Goldgar [116]
;
Olufunmilayo I,Olopade ;
Georgia,Chenevix-Trench ;
Timothy R,Rebbeck ;
Dezheng,Huo ;
CIMBA
作者单位：
Department of Medicine, University of Chicago, Chicago, IL, USA.
[1]
Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
[2]
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
[3]
Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
[4]
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
[5]
Department of Clinical Genetics, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.
[6]
Family Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
[7]
Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK.
[8]
Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland.;School of Medicine, University of Iceland, Reykjavik, Iceland.
[9]
North East Thames Regional Genetics Service, Great Ormond Street Hospital, London, UK.
[10]
Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
[11]
Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.;Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
[12]
Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany.;Institute of Clinical Molecular Biology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany.
[13]
Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
[14]
Division Laboratories, Pharmacy and Biomedical Genetics, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
[15]
Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
[16]
Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK.
[17]
Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.;Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
[18]
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
[19]
Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France.
[20]
Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.;Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.;Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.
[21]
Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden.
[22]
Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
[23]
Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain.
[24]
Department of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, USA.
[25]
Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
[26]
Section of Molecular Genetics, Dept. of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy.
[27]
Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.;Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia.
[28]
Department of Gynaecological Oncology, Chris O'Brien Lifehouse and The University of Sydney, Camperdown, NSW, Australia.
[29]
CRCHU de Québec- oncologie, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Québec, QC, Canada.
[30]
Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA.
[31]
Centre for Medical Genetics, Ghent University, Gent, Belgium.
[32]
Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
[33]
Service de Génétique, CHU de Besançon, Besançon, France.
[34]
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
[35]
Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA.
[36]
Unité d'Oncogénétique, ICO-Centre René Gauducheau, Saint Herblain, France.
[37]
Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital Vall d'Hebron, Barcelona, Spain.
[38]
Department of Genetics, University of Pretoria, Arcadia, South Africa.
[39]
Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, UK.
[40]
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.;Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
[41]
Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
[42]
Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
[43]
Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.;Manchester Centre for Genomic Medicine, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
[44]
Unité d'oncogénétique, Centre de Lutte Contre le Cancer, Centre Georges-François Leclerc, Dijon, France.;Centre de Génétique, CHU Dijon, Dijon, France.
[45]
Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Bellvitge Biomedical Research Institute, Catalan Institute of Oncology), CIBERONC, Barcelona, Spain.
[46]
Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
[47]
The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.;Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
[48]
Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, CA, USA.
[49]
Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA, USA.
[50]
Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany.
[51]
Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.
[52]
Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS, USA.
[53]
Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
[54]
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[55]
Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France.;Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.;Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
[56]
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
[57]
Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL, USA.;The University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
[58]
N.N. Petrov Institute of Oncology, St. Petersburg, Russia.
[59]
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
[60]
Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
[61]
Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.;Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland.
[62]
Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania.;State Research Institute, Innovative Medicine Center, Vilnius, CA, Lithuania.
[63]
Department of Medicine, Division of Oncology, and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
[64]
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
[65]
Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
[66]
The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.
[67]
Département de Génétique, CHU de Grenoble, Grenoble, France.
[68]
Genetic Epidemiology of Cancer team, Inserm U900, Paris, France.;Institut Curie, Paris, France.
[69]
Genetic Epidemiology of Cancer team, Inserm U900, Paris, France.;Institut Curie, Paris, France.;Mines ParisTech, Fontainebleau, France.
[70]
Department of Clinical Genetics, Amsterdam UMC, Location VU University Medical Center, Amsterdam, The Netherlands.
[71]
Department of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany.
[72]
NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY, USA.
[73]
Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
[74]
Service de Génétique, Institut Curie, Paris, France.
[75]
Clinical Cancer Genomics, City of Hope, Duarte, CA, USA.
[76]
Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
[77]
Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
[78]
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
[79]
Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.;Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
[80]
Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
[81]
West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, UK.
[82]
Department of Genetics, University Medical Center Groningen, University Groningen, Groningen, The Netherlands.
[83]
Department of Molecular Medicine, University La Sapienza, Rome, Italy.
[84]
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
[85]
Genome Diagnostics Program, IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.
[86]
Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
[87]
Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
[88]
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
[89]
School of Women's and Children's Health, Faculty of Medicine, University of NSW Sydney, Sydney, NSW, Australia.;The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW, Australia.
[90]
Clinical Genetics, Karolinska Institutet, Stockholm, Sweden.
[91]
Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.
[92]
Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
[93]
Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, IL, USA.
[94]
Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
[95]
Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA, USA.
[96]
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.;Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.
[97]
Wessex Clinical Genetics Service, University Hospitals Southampton NHS Trust, Southampton, UK.
[98]
Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Center, Québec City, QC, Canada.
[99]
Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.
[100]
Service de Génétique, Institut Curie, Paris, France.;Department of Tumour Biology, INSERM U830, Paris, France.;Université Paris Descartes, Paris, France.
[101]
Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.;Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.
[102]
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
[103]
Department of Clinical Genetics, Odense University Hospital, Odence C, Denmark.
[104]
Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, Canada.;Department of Medical Genetics, University of Cambridge, Cambridge, UK.
[105]
Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA.
[106]
Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
[107]
Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
[108]
Department of Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
[109]
Department of Medical Oncology, CHU Dupuytren, Limoges, France.
[110]
Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK.
[111]
Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
[112]
Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
[113]
Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA.
[114]
Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Dana-Farber Cancer Institute, Boston, MA, USA.
[115]
Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA. dhuo@health.bsd.uchicago.edu.;Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. dhuo@health.bsd.uchicago.edu.
[116]
医学主题词
成年人(Adult);老年人(Aged);身高(Body Height);人体质量指数(Body Mass Index);女(雌)性(Female);基因, BRCA1(Genes, BRCA1);基因, BRCA2(Genes, BRCA2);杂合子(Heterozygote);人类(Humans);孟德尔随机化分析(Mendelian Randomization Analysis);绝经期(Menopause);中年人(Middle Aged);突变(Mutation);卵巢肿瘤(Ovarian Neoplasms);比例危险度模型(Proportional Hazards Models)
DOI
10.1038/s41416-019-0492-8
PMID
31213659
发布时间
2025-05-30
- 浏览3
British journal of cancer
British journal of cancer
180-192页
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