换一批
换一批Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers.
作者：
Frank,Qian [1]
;
Matti A,Rookus [2]
;
Goska,Leslie [3]
;
Harvey A,Risch [4]
;
Mark H,Greene [5]
;
Cora M,Aalfs [6]
;
Muriel A,Adank [7]
;
Julian,Adlard [8]
;
Bjarni A,Agnarsson [9]
;
Munaza,Ahmed [10]
;
Kristiina,Aittomäki [11]
;
Irene L,Andrulis [12]
;
Norbert,Arnold [13]
;
Banu K,Arun [14]
;
Margreet G E M,Ausems [15]
;
Jacopo,Azzollini [16]
;
Daniel,Barrowdale [3]
;
Julian,Barwell [17]
;
Javier,Benitez [18]
;
Katarzyna,Białkowska [19]
;
Valérie,Bonadona [20]
;
Julika,Borde [21]
;
Ake,Borg [22]
;
Angela R,Bradbury [23]
;
Joan,Brunet [24]
;
Saundra S,Buys [25]
;
Trinidad,Caldés [26]
;
Maria A,Caligo [27]
;
Ian,Campbell [28]
;
Jonathan,Carter [29]
;
Jocelyne,Chiquette [30]
;
Wendy K,Chung [31]
;
Kathleen B M,Claes [32]
;
J Margriet,Collée [33]
;
Marie-Agnès,Collonge-Rame [34]
;
Fergus J,Couch [35]
;
Mary B,Daly [36]
;
Capucine,Delnatte [37]
;
Orland,Diez [38]
;
Susan M,Domchek [23]
;
Cecilia M,Dorfling [39]
;
Jacqueline,Eason [40]
;
Douglas F,Easton [41]
;
Ros,Eeles [42]
;
Christoph,Engel [43]
;
D Gareth,Evans [44]
;
Laurence,Faivre [45]
;
Lidia,Feliubadaló [46]
;
Lenka,Foretova [47]
;
Eitan,Friedman [48]
;
Debra,Frost [3]
;
Patricia A,Ganz [49]
;
Judy,Garber [50]
;
Vanesa,Garcia-Barberan [25]
;
Andrea,Gehrig [51]
;
Gord,Glendon [52]
;
Andrew K,Godwin [53]
;
Encarna B,Gómez Garcia [54]
;
Ute,Hamann [55]
;
Jan,Hauke [56]
;
John L,Hopper [57]
;
Peter J,Hulick [58]
;
Evgeny N,Imyanitov [59]
;
Claudine,Isaacs [60]
;
Louise,Izatt [61]
;
Anna,Jakubowska [62]
;
Ramunas,Janavicius [63]
;
Esther M,John [64]
;
Beth Y,Karlan [65]
;
Carolien M,Kets [66]
;
Yael,Laitman [67]
;
Conxi,Lázaro [46]
;
Dominique,Leroux [68]
;
Jenny,Lester [65]
;
Fabienne,Lesueur [69]
;
Jennifer T,Loud [5]
;
Jan,Lubiński [19]
;
Alicja,Łukomska [19]
;
Lesley,McGuffog [3]
;
Noura,Mebirouk [70]
;
Hanne E J,Meijers-Heijboer [71]
;
Alfons,Meindl [72]
;
Austin,Miller [73]
;
Marco,Montagna [74]
;
Thea M,Mooij [2]
;
Emmanuelle,Mouret-Fourme [75]
;
Katherine L,Nathanson [23]
;
Bita,Nehoray [76]
;
Susan L,Neuhausen [77]
;
Heli,Nevanlinna [78]
;
Finn C,Nielsen [79]
;
Kenneth,Offit [80]
;
Edith,Olah [81]
;
Kai-Ren,Ong [82]
;
Jan C,Oosterwijk [83]
;
Laura,Ottini [84]
;
Michael T,Parsons [85]
;
Paolo,Peterlongo [86]
;
Georg,Pfeiler [87]
;
Nisha,Pradhan [88]
;
Paolo,Radice [89]
;
Susan J,Ramus [90]
;
Johanna,Rantala [91]
;
Gad,Rennert [92]
;
Mark,Robson [93]
;
Gustavo C,Rodriguez [94]
;
Ritu,Salani [95]
;
Maren T,Scheuner [96]
;
Rita K,Schmutzler [97]
;
Payal D,Shah [23]
;
Lucy E,Side [98]
;
Jacques,Simard [99]
;
Christian F,Singer [87]
;
Doris,Steinemann [100]
;
Dominique,Stoppa-Lyonnet [101]
;
Yen Yen,Tan [87]
;
Manuel R,Teixeira [102]
;
Mary Beth,Terry [103]
;
Mads,Thomassen [104]
;
Marc,Tischkowitz [105]
;
Silvia,Tognazzo [74]
;
Amanda E,Toland [106]
;
Nadine,Tung [107]
;
Christi J,van Asperen [108]
;
Klaartje,van Engelen [109]
;
Elizabeth J,van Rensburg [39]
;
Laurence,Venat-Bouvet [110]
;
Jeroen,Vierstraete [32]
;
Gabriel,Wagner [87]
;
Lisa,Walker [111]
;
Jeffrey N,Weitzel [76]
;
Drakoulis,Yannoukakos [112]
;
KConFab Investigators [3]
;
HEBON Investigators [113]
;
GEMO Study Collaborators [114]
;
EMBRACE Collaborators [85]
;
Antonis C,Antoniou [115]
;
David E,Goldgar [116]
;
Olufunmilayo I,Olopade ;
Georgia,Chenevix-Trench ;
Timothy R,Rebbeck ;
Dezheng,Huo ;
CIMBA
作者单位：
Department of Medicine, University of Chicago, Chicago, IL, USA.
[1]
Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
[2]
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
[3]
Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
[4]
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
[5]
Department of Clinical Genetics, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.
[6]
Family Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
[7]
Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK.
[8]
Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland.;School of Medicine, University of Iceland, Reykjavik, Iceland.
[9]
North East Thames Regional Genetics Service, Great Ormond Street Hospital, London, UK.
[10]
Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
[11]
Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.;Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
[12]
Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany.;Institute of Clinical Molecular Biology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany.
[13]
Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
[14]
Division Laboratories, Pharmacy and Biomedical Genetics, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
[15]
Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
[16]
Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK.
[17]
Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.;Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
[18]
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
[19]
Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France.
[20]
Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.;Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.;Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.
[21]
Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden.
[22]
Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
[23]
Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain.
[24]
Department of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, USA.
[25]
Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
[26]
Section of Molecular Genetics, Dept. of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy.
[27]
Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.;Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia.
[28]
Department of Gynaecological Oncology, Chris O'Brien Lifehouse and The University of Sydney, Camperdown, NSW, Australia.
[29]
CRCHU de Québec- oncologie, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Québec, QC, Canada.
[30]
Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA.
[31]
Centre for Medical Genetics, Ghent University, Gent, Belgium.
[32]
Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
[33]
Service de Génétique, CHU de Besançon, Besançon, France.
[34]
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
[35]
Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA.
[36]
Unité d'Oncogénétique, ICO-Centre René Gauducheau, Saint Herblain, France.
[37]
Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital Vall d'Hebron, Barcelona, Spain.
[38]
Department of Genetics, University of Pretoria, Arcadia, South Africa.
[39]
Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, UK.
[40]
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.;Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
[41]
Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
[42]
Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
[43]
Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.;Manchester Centre for Genomic Medicine, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
[44]
Unité d'oncogénétique, Centre de Lutte Contre le Cancer, Centre Georges-François Leclerc, Dijon, France.;Centre de Génétique, CHU Dijon, Dijon, France.
[45]
Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Bellvitge Biomedical Research Institute, Catalan Institute of Oncology), CIBERONC, Barcelona, Spain.
[46]
Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
[47]
The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.;Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
[48]
Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, CA, USA.
[49]
Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA, USA.
[50]
Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany.
[51]
Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.
[52]
Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS, USA.
[53]
Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
[54]
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[55]
Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France.;Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.;Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
[56]
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
[57]
Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL, USA.;The University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
[58]
N.N. Petrov Institute of Oncology, St. Petersburg, Russia.
[59]
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
[60]
Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
[61]
Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.;Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland.
[62]
Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania.;State Research Institute, Innovative Medicine Center, Vilnius, CA, Lithuania.
[63]
Department of Medicine, Division of Oncology, and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
[64]
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
[65]
Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
[66]
The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.
[67]
Département de Génétique, CHU de Grenoble, Grenoble, France.
[68]
Genetic Epidemiology of Cancer team, Inserm U900, Paris, France.;Institut Curie, Paris, France.
[69]
Genetic Epidemiology of Cancer team, Inserm U900, Paris, France.;Institut Curie, Paris, France.;Mines ParisTech, Fontainebleau, France.
[70]
Department of Clinical Genetics, Amsterdam UMC, Location VU University Medical Center, Amsterdam, The Netherlands.
[71]
Department of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany.
[72]
NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY, USA.
[73]
Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
[74]
Service de Génétique, Institut Curie, Paris, France.
[75]
Clinical Cancer Genomics, City of Hope, Duarte, CA, USA.
[76]
Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
[77]
Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
[78]
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
[79]
Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.;Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
[80]
Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
[81]
West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, UK.
[82]
Department of Genetics, University Medical Center Groningen, University Groningen, Groningen, The Netherlands.
[83]
Department of Molecular Medicine, University La Sapienza, Rome, Italy.
[84]
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
[85]
Genome Diagnostics Program, IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.
[86]
Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
[87]
Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
[88]
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
[89]
School of Women's and Children's Health, Faculty of Medicine, University of NSW Sydney, Sydney, NSW, Australia.;The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW, Australia.
[90]
Clinical Genetics, Karolinska Institutet, Stockholm, Sweden.
[91]
Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.
[92]
Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
[93]
Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, IL, USA.
[94]
Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
[95]
Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA, USA.
[96]
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.;Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.
[97]
Wessex Clinical Genetics Service, University Hospitals Southampton NHS Trust, Southampton, UK.
[98]
Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Center, Québec City, QC, Canada.
[99]
Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.
[100]
Service de Génétique, Institut Curie, Paris, France.;Department of Tumour Biology, INSERM U830, Paris, France.;Université Paris Descartes, Paris, France.
[101]
Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.;Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.
[102]
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
[103]
Department of Clinical Genetics, Odense University Hospital, Odence C, Denmark.
[104]
Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, Canada.;Department of Medical Genetics, University of Cambridge, Cambridge, UK.
[105]
Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA.
[106]
Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
[107]
Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
[108]
Department of Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
[109]
Department of Medical Oncology, CHU Dupuytren, Limoges, France.
[110]
Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK.
[111]
Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
[112]
Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
[113]
Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA.
[114]
Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Dana-Farber Cancer Institute, Boston, MA, USA.
[115]
Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA. dhuo@health.bsd.uchicago.edu.;Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. dhuo@health.bsd.uchicago.edu.
[116]
主题词
成年人(Adult);老年人(Aged);身高(Body Height);人体质量指数(Body Mass Index);女(雌)性(Female);基因, BRCA1(Genes, BRCA1);基因, BRCA2(Genes, BRCA2);杂合子(Heterozygote);人类(Humans);孟德尔随机化分析(Mendelian Randomization Analysis);绝经期(Menopause);中年人(Middle Aged);突变(Mutation);卵巢肿瘤(Ovarian Neoplasms);比例危险度模型(Proportional Hazards Models)
DOI
10.1038/s41416-019-0492-8
PMID
31213659
发布时间
2024-10-03
- 浏览2
British journal of cancer
British journal of cancer
180-192页
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