A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer's disease.

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第一作者： Yuya,Asanomi

第一单位： Division for Genomic Medicine, Medical Genome Center, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.

作者： Yuya,Asanomi ^[1] ; Daichi,Shigemizu ^[1] ; Akinori,Miyashita ^[2] ; Risa,Mitsumori ^[3] ; Taiki,Mori ^[4] ; Norikazu,Hara ^[1] ; Kaoru,Ito ^[1] ; Shumpei,Niida ^[4] ; Takeshi,Ikeuchi ^[5] ; Kouichi,Ozaki ^[6]

作者单位： Division for Genomic Medicine, Medical Genome Center, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan. ^[1] Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. ^[2] Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. ^[3] Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan. ^[4] Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. ^[5] Medical Genome Center, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan. ^[6] Division for Genomic Medicine, Medical Genome Center, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan. ozakikk@ncgg.go.jp. ^[7] Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. ozakikk@ncgg.go.jp. ^[8]

关键词 Alzheimer’s disease Genetic risk factor Inflammation Rare functional variant SHARPIN