A cell topography-based mechanism for ligand discrimination by the T cell receptor.

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第一作者： Ricardo A,Fernandes

第一单位： Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, OX3 9DS Oxford, United Kingdom.

作者： Ricardo A,Fernandes ^[1] ; Kristina A,Ganzinger ^[2] ; Justin C,Tzou ^[3] ; Peter,Jönsson ^[4] ; Steven F,Lee ^[3] ; Matthieu,Palayret ^[3] ; Ana Mafalda,Santos ^[3] ; Alexander R,Carr ^[1] ; Aleks,Ponjavic ^[2] ; Veronica T,Chang ^[3] ; Charlotte,Macleod ^[3] ; B Christoffer,Lagerholm ^[1] ; Alan E,Lindsay ^[2] ; Omer,Dushek ^[3] ; Andreas,Tilevik ^[1] ; Simon J,Davis ^[5] ; David,Klenerman ^[6]

作者单位： Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, OX3 9DS Oxford, United Kingdom. ^[1] Medical Research Council Human Immunology Unit, John Radcliffe Hospital, University of Oxford, OX3 9DS Oxford, United Kingdom. ^[2] Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom. ^[3] Department of Applied & Computational Mathematics & Statistics, University of Notre Dame, Notre Dame, IN 46556. ^[4] Mathematics Department, University of British Columbia, Vancouver, BC V6T 1Z2, Canada. ^[5] Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, United Kingdom. ^[6] Wolfson Centre for Mathematical Biology, University of Oxford, OX1 3RE Oxford, United Kingdom. ^[7] School of Bioscience, University of Skövde, 541 28 Skövde, Sweden andreas.tilevik@his.se simon.davis@imm.ox.ac.uk dk10012@cam.ac.uk. ^[8] Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, OX3 9DS Oxford, United Kingdom; andreas.tilevik@his.se simon.davis@imm.ox.ac.uk dk10012@cam.ac.uk. ^[9] Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom; andreas.tilevik@his.se simon.davis@imm.ox.ac.uk dk10012@cam.ac.uk. ^[10]

关键词 T cell receptor dwell time microvilli receptor triggering single-molecule imaging