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首页> eLife> Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development.

Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development.

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第一作者： Chris,Cho

第一单位： Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.

作者： Chris,Cho ^[1] ; Yanshu,Wang ^[2] ; Philip M,Smallwood ^[2] ; John,Williams ^[2] ; Jeremy,Nathans ^[3]

作者单位： Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States. ^[1] Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.;Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United States. ^[2] Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.;Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United States.;Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.;Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, United States. ^[3]

关键词 CNS angiogenesis Gpr124 Reck Wnt7 blood-brain barrier canonical Wnt signaling developmental biology mouse neuroscience

主题词氨基酸序列(Amino Acid Sequence);动物(Animals);碱基序列(Base Sequence);脑(Brain);胚胎, 哺乳动物(Embryo, Mammalian);Frizzled受体(Frizzled Receptors);GPI连接蛋白质类(GPI-Linked Proteins);HEK293细胞(HEK293 Cells);人类(Humans);配体(Ligands);萤光素酶类(Luciferases);小鼠(Mice);突变(Mutation);新生血管化, 生理性(Neovascularization, Physiologic);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);信号传导(Signal Transduction);Wnt蛋白质类(Wnt Proteins)

DOI 10.7554/eLife.47300

PMID 31225798

发布时间 2023-07-14

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