GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis.

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第一作者： Michele,Biagioli

第一单位： Dipartimento di Scienze Biomediche e Chirurgiche, Università di Perugia, Perugia, Italy.

作者： Michele,Biagioli ^[1] ; Adriana,Carino ^[1] ; Chiara,Fiorucci ^[1] ; Silvia,Marchianò ^[1] ; Cristina,Di Giorgio ^[1] ; Rosalinda,Roselli ^[2] ; Margherita,Magro ^[1] ; Eleonora,Distrutti ^[3] ; Oxana,Bereshchenko ^[4] ; Paolo,Scarpelli ^[5] ; Angela,Zampella ^[2] ; Stefano,Fiorucci ^[6]

作者单位： Dipartimento di Scienze Biomediche e Chirurgiche, Università di Perugia, Perugia, Italy. ^[1] Dipartimento di Farmacia, Università di Napoli Federico II, Napoli, Italy. ^[2] SC di Gastroenterologia ed Epatologia, Azienda Ospedaliera di Perugia, Perugia, Italy. ^[3] Dipartimento di Scienze Biomediche e Chirurgiche, Università di Perugia, Perugia, Italy; Department of Medicine, University of Perugia, Perugia, Italy. ^[4] University of Perugia, Department of Experimental Medicine, Perugia, Italy. ^[5] Dipartimento di Scienze Biomediche e Chirurgiche, Università di Perugia, Perugia, Italy. Electronic address: stefano.fiorucci@unipg.it. ^[6]

关键词 Autoimmune Hepatitis Bile Acids GPBAR1 IL-10 Interleukin-10 NKT Natural Killer T Cells

主题词动物(Animals);细胞系(Cell Line);胆甾烷醇类(Cholestanols);伴刀豆球蛋白A(Concanavalin A);疾病模型, 动物(Disease Models, Animal);半乳糖神经酰胺类(Galactosylceramides);Hep G2细胞(Hep G2 Cells);肝炎(Hepatitis);人类(Humans);白细胞介素10(Interleukin-10);男(雄)性(Male);小鼠(Mice);自然杀伤T细胞(Natural Killer T-Cells);受体, G-蛋白偶联(Receptors, G-Protein-Coupled)

DOI 10.1016/j.jcmgh.2019.06.003

PMID 31226434

发布时间 2021-01-17

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Cellular and molecular gastroenterology and hepatology

2019年8卷3期

447-473页

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GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis.

Cellular and molecular gastroenterology and hepatology

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Cellular and molecular gastroenterology and hepatology

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GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis.

Cellular and molecular gastroenterology and hepatology

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Cellular and molecular gastroenterology and hepatology

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