首页> Cancer discovery> V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer.

V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer.

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第一作者： Yijun,Gao

第一单位： Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.

作者： Yijun,Gao ^[1] ; Ann,Maria ^[1] ; Na,Na ^[1] ; Arnaud,da Cruz Paula ^[2] ; Alexander N,Gorelick ^[3] ; Jaclyn F,Hechtman ^[2] ; Julianne,Carson ^[1] ; Robert A,Lefkowitz ^[4] ; Britta,Weigelt ^[2] ; Barry S,Taylor ^[5] ; HuiYong,Zhao ^[1] ; Jorge S,Reis-Filho ^[2] ; Elisa,de Stanchina ^[1] ; Neal,Rosen ^[6] ; Zhan,Yao ^[6] ; Rona,Yaeger ^[7]

作者单位： Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York. ^[1] Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. ^[2] Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.;Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. ^[3] Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York. ^[4] Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.;Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.;Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York. ^[5] Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.;Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. ^[6] Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. yaegerr@mskcc.org. ^[7]

医学主题词成年人(Adult);别构调节(Allosteric Regulation);氨基酸取代(Amino Acid Substitution);动物(Animals);苯咪唑类(Benzimidazoles);结合部位(Binding Sites);细胞系, 肿瘤(Cell Line, Tumor);结肠肿瘤(Colonic Neoplasms);抗药性, 肿瘤(Drug Resistance, Neoplasm);女(雌)性(Female);人类(Humans);MAP激酶激酶1(MAP Kinase Kinase 1);小鼠(Mice);NIH 3T3细胞(NIH 3T3 Cells);蛋白质结合(Protein Binding);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质B-raf(Proto-Oncogene Proteins B-raf)

DOI 10.1158/2159-8290.CD-19-0356

PMID 31227518

发布时间 2020-08-03

基金项目

U54 OD020355/OD/NIH HHS/United States P30 CA008748/CA/NCI NIH HHS/United States R01 CA233736/CA/NCI NIH HHS/United States R35 CA210085/CA/NCI NIH HHS/United States R01 CA204749/CA/NCI NIH HHS/United States

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