Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues.

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第一作者： Dobeen,Hwang

第一单位： Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.

作者： Dobeen,Hwang ^[1] ; Napon,Nilchan ^[2] ; Alex R,Nanna ^[3] ; Xiaohai,Li ^[4] ; Michael D,Cameron ^[4] ; William R,Roush ^[2] ; HaJeung,Park ^[5] ; Christoph,Rader ^[6]

作者单位： Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA. ^[1] Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458, USA. ^[2] Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458, USA. ^[3] Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA. ^[4] X-Ray Crystallography Core, The Scripps Research Institute, Jupiter, FL 33458, USA. ^[5] Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address: crader@scripps.edu. ^[6]

关键词 Site-specific antibody conjugation antibody-drug conjugates cancer therapy catalytic antibodies dual variable domain orthogonal antibody conjugation phenylglyoxal β-lactam

主题词抗体(Antibodies);精氨酸(Arginine);细胞系(Cell Line);结晶学, X线(Crystallography, X-Ray);半抗原(Haptens);人类(Humans);免疫轭合物(Immunoconjugates);免疫球蛋白轻链(Immunoglobulin Light Chains);赖氨酸(Lysine);苯甲酰甲醛(Phenylglyoxal)

DOI 10.1016/j.chembiol.2019.05.010

PMID 31231031

发布时间 2020-09-19

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Cell chemical biology

2019年26卷9期

1229-1239.e9页

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Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues.

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Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues.

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