Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry.

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作者： Deka,Prismawan ^[1] ; Ramon,van der Vlag ^[2] ; Hao,Guo ^[1] ; Frank J,Dekker ^[2] ; Anna K H,Hirsch ^[2]

作者单位： Stratingh Institute for Chemistry University of Groningen, Nijenborgh 7 NL-9747 AG Groningen The Netherlands. ^[1] Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP) University of Groningen, Antonius Deusinglaan 1, NL- 9713 AV Groningen The Netherlands. ^[2] Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI) Department of Drug Design and Optimization Campus Building E8.1 DE-66123 Saarbrücken Germany. ^[3] Department of Pharmacy Saarland University DE-66123 Saarbrücken Germany. ^[4]

关键词 15-lipoxygenase-1 acylhydrazone combinatorial chemistry enzyme inhibitors structure–activity relationships

DOI 10.1002/hlca.201900040

PMID 31231138

发布时间 2023-10-12

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