Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria.

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作者： Shuang,Liang ^[1] ; Zhenyu,Zhong ^[2] ; So Yeon,Kim ^[3] ; Ryosuke,Uchiyama ^[3] ; Yoon Seok,Roh ^[4] ; Hiroshi,Matsushita ^[3] ; Roberta A,Gottlieb ^[5] ; Ekihiro,Seki ^[6]

作者单位： Division of Gastroenterology, Department of Medicine, University of California San Diego School of Medicine, La Jolla, California 92093; Department of Immunology, University of Texas Southwestern Medical Center, Dallas Texas 75390. ^[1] Department of Immunology, University of Texas Southwestern Medical Center, Dallas Texas 75390. ^[2] Division of Digestive and Liver Diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048. ^[3] Division of Digestive and Liver Diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Pharmacy, Chungbuk National University College of Pharmacy, Cheongju, Chungbuk 28160, South Korea. ^[4] Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048. ^[5] Division of Digestive and Liver Diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048. Electronic address: Ekihiro.Seki@cshs.org. ^[6]

关键词 CC-chemokine ligand 10 CC-chemokine ligand 5 Toll-like receptor 4 (TLR4)alcohol alcoholic liver disease autophagy chemokine cytokine dysbiosis inflammasome innate immunity macrophage