Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model.

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作者： Chia-Hsuan,Fu ^[1] ; Daniel Maxim,Iascone ^[2] ; Iraklis,Petrof ^[1] ; Anupam,Hazra ^[2] ; Xiaohong,Zhang ^[2] ; Mark S,Pyfer ^[2] ; Umberto,Tosi ^[2] ; Brian F,Corbett ^[2] ; Jingli,Cai ^[2] ; Jason,Lee ^[3] ; Jin,Park ^[3] ; Lorraine,Iacovitti ^[2] ; Helen E,Scharfman ^[4] ; Grigori,Enikolopov ^[5] ; Jeannie,Chin ^[6]

作者单位： Memory & Brain Research Center, Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience and Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA. ^[1] Department of Neuroscience and Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA. ^[2] Memory & Brain Research Center, Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. ^[3] Departments of Psychiatry, Neuroscience, and Physiology and the Neuroscience Institute, New York University Langone Medical Center, New York, NY 10016, USA. ^[4] Center for Developmental Genetics and Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA. ^[5] Memory & Brain Research Center, Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience and Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: jeannie.chin@bcm.edu. ^[6]

关键词 Alzheimer cognition dentate gyrus epilepsy hippocampus memory mouse model neural stem cell pool neurogenesis seizure