hERG optimizations of IMB1603, discovery of alternative benzothiazinones as new antitubercular agents.

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作者： Kai,Lv ^[1] ; Apeng,Wang ^[1] ; Zeyu,Tao ^[1] ; Lei,Fu ^[2] ; Hongtao,Liu ^[3] ; Bin,Wang ^[2] ; Chao,Ma ^[1] ; Hongjian,Wang ^[1] ; Xican,Ma ^[1] ; Bing,Han ^[1] ; Auyu,Wang ^[4] ; Kai,Zhang ^[4] ; Mingliang,Liu ^[5] ; Yu,Lu ^[6]

作者单位： Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. ^[1] Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, 100149, China. ^[2] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Department of Pharmacy, Hebei General Hospital, Hebei, Shijiazhuang, 050051, China. ^[3] Department of Pharmaceutical Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China. ^[4] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: lmllyx@126.com. ^[5] Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, 100149, China. Electronic address: luyu4876@hotmail.com. ^[6]

关键词 Antitubercular agents Benzothiazinones Structure-activity relationships hERG