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Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs.

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第一作者： Nynke I,Kramer

第一单位： Institute for Risk Assessment Sciences, Utrecht University, PO Box 80177, 3508 TD, Utrecht, The Netherlands.

作者： Nynke I,Kramer ^[1] ; Yvette,Hoffmans ^[2] ; Siyao,Wu ^[2] ; Anette,Thiel ^[3] ; Natalie,Thatcher ^[4] ; Timothy E H,Allen ^[5] ; Sara,Levorato ^[6] ; Heinz,Traussnig ^[7] ; Stefan,Schulte ^[8] ; Alan,Boobis ^[9] ; Ivonne M C M,Rietjens ^[10] ; Mathieu,Vinken ^[11]

作者单位： Institute for Risk Assessment Sciences, Utrecht University, PO Box 80177, 3508 TD, Utrecht, The Netherlands. ^[1] Wageningen University and Research, Droevendaalsesteeg 4, 6708 PB, Wageningen, The Netherlands. ^[2] DSM Nutritional Products Ltd., Wurmisweg 576, 4303, Kaiseraugst, Switzerland. ^[3] Mondelēz International, Bournville Place, Bournville Ln, Birmingham, B30 2LU, UK. ^[4] Department of Chemistry, Centre for Molecular Informatics, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. ^[5] Unilever, Safety and Environmental Assurance Centre (SEAC), Sharnbrook, Bedford, MK441LQ, UK. ^[6] Mayr-Melnhof Karton Gesellschaft M.B.H., Frohnleiten Mill, Wannersdorf 80, 8130, Frohnleiten, Austria. ^[7] Department of Product Safety, BASF SE, 67056, Ludwigshafen, Germany. ^[8] Department of Medicine, Imperial College London, London, W12 0NN, UK. ^[9] Division of Toxicology, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands. ^[10] Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium. mathieu.vinken@vub.be. ^[11]

关键词 3Rs Acceptable daily intake Adverse outcome pathway Critical adverse effect Food additives

主题词食品添加剂(Food Additives);食品安全(Food Safety);人类(Humans);肾(Kidney);肝(Liver);无明显有害效应剂量(No-Observed-Adverse-Effect Level);危险性评估(Risk Assessment)

DOI 10.1007/s00204-019-02501-x

PMID 31256212

发布时间 2020-08-03

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