Investigating the reason for loss-of-function of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) caused by Y279C mutation through molecular dynamics simulation.

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作者： Wen-Shan,Liu ^[1] ; Rui-Rui,Wang ^[1] ; Wei-Ya,Li ^[1] ; Mei,Rong ^[1] ; Chi-Lu,Liu ^[1] ; Ying,Ma ^[1] ; Run-Ling,Wang ^[1]

作者单位： School of Pharmacy, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Tianjin Medical University, Tianjin, China. ^[1]

关键词 NSML SHP2WT SHP2Y279C molecular dynamics simulation

主题词人类(Humans);氢键合(Hydrogen Bonding);LEOPARD综合征(LEOPARD Syndrome);分子动力学模拟(Molecular Dynamics Simulation);突变(Mutation);蛋白质结构, 二级(Protein Structure, Secondary);蛋白质酪氨酸磷酸酶, 非受体11型(Protein Tyrosine Phosphatase, Non-Receptor Type 11)

DOI 10.1080/07391102.2019.1634641

PMID 31258001

发布时间 2022-05-31

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Journal of biomolecular structure & dynamics

2020年38卷9期

2509-2520页

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Investigating the reason for loss-of-function of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) caused by Y279C mutation through molecular dynamics simulation.

Journal of biomolecular structure & dynamics

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Journal of biomolecular structure & dynamics

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Investigating the reason for loss-of-function of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) caused by Y279C mutation through molecular dynamics simulation.

Journal of biomolecular structure & dynamics

相似文献

Journal of biomolecular structure & dynamics

相关期刊

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