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Genomic data analysis workflows for tumors from patient-derived xenografts (PDXs): challenges and guidelines.

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第一作者： Xing Yi,Woo

第一单位： The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06030, USA.

作者： Xing Yi,Woo ^[1] ; Anuj,Srivastava ^[1] ; Joel H,Graber ^[2] ; Vinod,Yadav ^[3] ; Vishal Kumar,Sarsani ^[4] ; Al,Simons ^[5] ; Glen,Beane ^[5] ; Stephen,Grubb ^[5] ; Guruprasad,Ananda ^[1] ; Rangjiao,Liu ^[6] ; Grace,Stafford ^[5] ; Jeffrey H,Chuang ^[1] ; Susan D,Airhart ^[5] ; R Krishna Murthy,Karuturi ^[1] ; Joshy,George ^[7] ; Carol J,Bult ^[8]

作者单位： The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06030, USA. ^[1] MDI Biological Laboratory, Bar Harbor, ME, 04609, USA. ^[2] The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06030, USA.;Present Address: Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. ^[3] The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, 04609, USA.;Present Address: University of Massachusetts, Amherst, MA, 01003, USA. ^[4] The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, 04609, USA. ^[5] The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06030, USA.;Present Address: Novogene Corporation, Rockville, MD, 20850, USA. ^[6] The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06030, USA. Joshy.George@jax.org. ^[7] The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, 04609, USA. Carol.Bult@jax.org. ^[8]

关键词 Bioinformatic analysis Copy number alterations DNA sequencing Gene expression Mouse stroma Patient-derived xenografts RNA sequencing SNP array Somatic mutation