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Chemokine Receptor Crystal Structures: What Can Be Learned from Them?

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第一作者： Marta,Arimont

第一单位： Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (M.A., R.L.); Institute for Molecular Cell Biology, Centre for Molecular Biomedicine, University Hospital Jena, Friedrich Schiller University, Jena, Germany (C.H.); and Sosei Heptares, Great Abington, Cambridge, United Kingdom (C.d.G.) m.arimontsegura@vu.nl.

作者： Marta,Arimont ^[1] ; Carsten,Hoffmann ^[2] ; Chris,de Graaf ^[2] ; Rob,Leurs ^[3]

作者单位： Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (M.A., R.L.); Institute for Molecular Cell Biology, Centre for Molecular Biomedicine, University Hospital Jena, Friedrich Schiller University, Jena, Germany (C.H.); and Sosei Heptares, Great Abington, Cambridge, United Kingdom (C.d.G.) m.arimontsegura@vu.nl. ^[1] Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (M.A., R.L.); Institute for Molecular Cell Biology, Centre for Molecular Biomedicine, University Hospital Jena, Friedrich Schiller University, Jena, Germany (C.H.); and Sosei Heptares, Great Abington, Cambridge, United Kingdom (C.d.G.). ^[2] Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (M.A., R.L.); Institute for Molecular Cell Biology, Centre for Molecular Biomedicine, University Hospital Jena, Friedrich Schiller University, Jena, Germany (C.H.); and Sosei Heptares, Great Abington, Cambridge, United Kingdom (C.d.G.) r.leurs@vu.nl. ^[3]

医学主题词动物(Animals);结晶学, X线(Crystallography, X-Ray);人类(Humans);蛋白质结合(Protein Binding);蛋白质结构, 二级(Protein Structure, Secondary);受体, 趋化因子(Receptors, Chemokine)

DOI 10.1124/mol.119.117168

PMID 31266800

发布时间 2025-02-13

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