The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes.

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作者： Ge,Qu ^[1] ; Aitao,Li ^[2] ; Carlos G,Acevedo-Rocha ^[3] ; Zhoutong,Sun ^[1] ; Manfred T,Reetz ^[1]

作者单位： Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin, 300308, China. ^[1] State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-resources, Hubei Key Laboratory of Industrial Biotechnology, College of Life Sciences, Hubei University, 368 Youyi Road, Wuchang Wuhan, 430062, China. ^[2] Biosyntia ApS, 2100, Copenhagen, Denmark. ^[3] Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim, Germany. ^[4] Department of Chemistry, Hans-Meerwein-Strasse 4, Philipps-University, 35032, Marburg, Germany. ^[5]

关键词 directed evolution iterative saturation mutagenesis machine learning stereoselectivity synthetic genes

主题词细菌(Bacteria);生物催化(Biocatalysis);定向分子进化(Directed Molecular Evolution);酶类(Enzymes);真菌(Fungi);诱变, 定点(Mutagenesis, Site-Directed);有机化学品(Organic Chemicals)

DOI 10.1002/anie.201901491

PMID 31267627

发布时间 2021-04-26

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