Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity.-论文-万方医学网

第一作者： Tamar,Farfel-Becker

第一单位： Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA.

作者： Tamar,Farfel-Becker ^[1] ; Joseph C,Roney ^[1] ; Xiu-Tang,Cheng ^[1] ; Sunan,Li ^[1] ; Sean R,Cuddy ^[1] ; Zu-Hang,Sheng ^[2]

作者单位： Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA. ^[1] Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA. Electronic address: shengz@ninds.nih.gov. ^[2]

医学主题词 ADP核糖基化因子(ADP-Ribosylation Factors);动物(Animals);自噬(Autophagy);轴突运输(Axonal Transport);轴突(Axons);组织蛋白酶类(Cathepsins);女(雌)性(Female);神经节, 脊(Ganglia, Spinal);葡糖苷酰鞘氨醇酶(Glucosylceramidase);HEK293细胞(HEK293 Cells);内环境稳定(Homeostasis);人类(Humans);溶酶体(Lysosomes);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);神经元(Neurons);蛋白质转运(Protein Transport);α突触核蛋白(alpha-Synuclein)

DOI 10.1016/j.celrep.2019.06.013

PMID 31269450

发布时间 2025-05-30

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Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity.

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Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity.

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