A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease.

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作者： Yuji,Amano ^[1] ; Yohei,Akazawa ^[2] ; Jun,Yasuda ^[3] ; Kazuhisa,Yoshino ^[4] ; Katsuhiko,Kojima ^[1] ; Norimoto,Kobayashi ^[1] ; Satoshi,Matsuzaki ^[2] ; Masao,Nagasaki ^[2] ; Yosuke,Kawai ^[3] ; Naoko,Minegishi ^[4] ; Noriko,Ishida ^[5] ; Noriko,Motoki ^[3] ; Akira,Hachiya ^[4] ; Yozo,Nakazawa ^[3] ; Masayuki,Yamamoto ^[4] ; Kenichi,Koike ^[3] ; Toshikazu,Takeshita ^[4]

作者单位： Department of Microbiology and Immunology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan. ^[1] Department of Pediatrics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan. ^[2] Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan. ^[3] Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan. ^[4] Graduate School of Information Science, Tohoku University, 6-3-09, Aramaki Aza-Aoba, Aoba-ku, Sendai, Miyagi, 980-8579, Japan. ^[5] Shinonoi General Hospital, Minami Nagano Center, 666-1 Shinonoi, Nagano City, Nagano, 388-8004, Japan. ^[6] Department of Microbiology and Immunology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan. takesit@shinshu-u.ac.jp. ^[7]

关键词 IVIG-resistance Interleukin-4 receptor Kawasaki disease Single nucleotide variant