Carboplatin Enhances the Activity of Human Transient Receptor Potential Ankyrin 1 through the Cyclic AMP-Protein Kinase A-A-Kinase Anchoring Protein (AKAP) Pathways.

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作者： Kanako,Miyano ^[1] ; Seiji,Shiraishi ^[1] ; Koichiro,Minami ^[1] ; Yuka,Sudo ^[2] ; Masami,Suzuki ^[3] ; Toru,Yokoyama ^[1] ; Kiyoshi,Terawaki ^[4] ; Miki,Nonaka ^[1] ; Hiroaki,Murata ^[1] ; Yoshikazu,Higami ^[2] ; Yasuhito,Uezono ^[3]

作者单位： Division of Cancer Pathophysiology, National Cancer Research Institute, Tokyo 104-0045, Japan. ^[1] Emergency Life-Saving Technique Academy of Tokyo (ELSTA TOKYO), Hachioji-shi, Tokyo 192-0364, Japan. ^[2] Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, Tochigi 329-0498, Japan. ^[3] Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba 278-8510, Japan. ^[4] Department of Anesthesiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan. ^[5] Translational Research Center, Research Institute of Science and Technology, Tokyo University of Science, Chiba 278-8510, Japan. ^[6] Division of Cancer Pathophysiology, National Cancer Research Institute, Tokyo 104-0045, Japan. yuezono@ncc.go.jp. ^[7] Division of Supportive Care Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Tokyo 104-0045, Japan. yuezono@ncc.go.jp. ^[8] Innovation Center for Supportive, Palliative and Psychosocial Care, National Cancer Center, Tokyo 104-0045, Japan. yuezono@ncc.go.jp. ^[9] Department of Comprehensive Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan. yuezono@ncc.go.jp. ^[10]

关键词 AKAP CIPN PKA TRPA1 cAMP carboplatin