Radiosynthesis and evaluation of a novel monoacylglycerol lipase radiotracer: 1,1,1,3,3,3-hexafluoropropan-2-yl-3-(1-benzyl-1H-pyrazol-3-yl)azetidine-1-[<sup>11</sup>C]carboxylate.

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第一作者： Wakana,Mori

第一单位： Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

作者： Wakana,Mori ^[1] ; Akiko,Hatori ^[1] ; Yiding,Zhang ^[1] ; Yusuke,Kurihara ^[2] ; Tomoteru,Yamasaki ^[1] ; Lin,Xie ^[1] ; Katsushi,Kumata ^[1] ; Kuan,Hu ^[1] ; Masayuki,Fujinaga ^[1] ; Ming-Rong,Zhang ^[3]

作者单位： Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. ^[1] Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan; SHI Accelerator Service Co., 1-17-6 Osaki, Shinagawa-ku, Tokyo 141-0032, Japan. ^[2] Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. Electronic address: zhang.ming-rong@qst.go.jp. ^[3]

关键词 Irreversible binding MAGL Monoacylglycerol lipase Positron emission tomography [(11)C]phosgene

主题词动物(Animals);氨甲酸酯类(Carbamates);碳放射性同位素(Carbon Radioisotopes);单酰基甘油酯脂酶类(Monoacylglycerol Lipases);大鼠(Rats)

DOI 10.1016/j.bmc.2019.06.037

PMID 31278005

发布时间 2020-09-15

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