Automated therapy preparation of isoleucine formulations using 3D printing for the treatment of MSUD: First single-centre, prospective, crossover study in patients.

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作者： Alvaro,Goyanes ^[1] ; Christine M,Madla ^[2] ; Aysha,Umerji ^[2] ; Goretti,Duran Piñeiro ^[3] ; Jose Maria,Giraldez Montero ^[3] ; María Jesús,Lamas Diaz ^[3] ; Miguel,Gonzalez Barcia ^[3] ; Farhan,Taherali ^[2] ; Paula,Sánchez-Pintos ^[4] ; Maria-Luz,Couce ^[4] ; Simon,Gaisford ^[5] ; Abdul W,Basit ^[6]

作者单位： FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK; Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma Group (GI-1645), Universidade de Santiago de Compostela, 15782, Spain. Electronic address: a.goyanes@FabRx.co.uk. ^[1] UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. ^[2] Pharmacy Department, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Travesía Choupana s/n, Santiago de Compostela 15706, Spain. ^[3] Servicio de Neonatología, Unidad de Diagnóstico y Tratamiento de Enfermedades Metabólicas Congénitas, Hospital Clínico Universitario de Santiago de Compostela, Universidad de Santiago de Compostela, IDIS, CIBERER, MetabERN, Spain. ^[4] FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. ^[5] FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. Electronic address: a.basit@ucl.ac.uk. ^[6]

关键词 3D printed drug products Drug compounding Maple syrup urine disease Metabolic disorders Orphan diseases Pediatric pharmacy Personalized medicine Three dimensional printing