Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors.

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第一作者： Guangzhe,Li

第一单位： Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116023, China; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.

作者： Guangzhe,Li ^[1] ; Huijuan,Dong ^[2] ; Yao,Ma ^[3] ; Kun,Shao ^[4] ; Yueqing,Li ^[1] ; Xiaodan,Wu ^[2] ; Shisheng,Wang ^[5] ; Yujie,Shao ^[2] ; Weijie,Zhao ^[1]

作者单位： Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116023, China; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China. ^[1] Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116023, China. ^[2] Dalian Hospital of Obstetrics and Gynaecology, Dalian 116083, China. ^[3] State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China. ^[4] Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116023, China; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China. Electronic address: wangss@dlut.edu.cn. ^[5]

关键词 Anti-tumor Hypoxia inducible factor (HIF)-1 Marine alkaloids Neolamellarin A Structure-activity relationship