Phase Ib Trial To Evaluate the Safety and Pharmacokinetics of Multiple Ascending Doses of Filociclovir (MBX-400, Cyclopropavir) in Healthy Volunteers.

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第一作者： Nadine G,Rouphael

第一单位： The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, Georgia, USA nroupha@emory.edu.

作者： Nadine G,Rouphael ^[1] ; Selwyn J,Hurwitz ^[2] ; Mari,Hart ^[3] ; Allison,Beck ^[3] ; Evan J,Anderson ^[4] ; Gregory,Deye ^[5] ; Blaire,Osborn ^[5] ; Shu Yi,Cai ^[5] ; Chris,Focht ^[6] ; Cyrille,Amegashie ^[6] ; Terry L,Bowlin ^[7] ; Jennifer,Brooks ^[7] ; Mark J,Mulligan ^[8]

作者单位： The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, Georgia, USA nroupha@emory.edu. ^[1] Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA. ^[2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, Georgia, USA. ^[3] Emory Children's Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA. ^[4] Division of Microbiology and Infectious Diseases, NIAID, NIH, Rockville, Maryland, USA. ^[5] The Emmes Company, LLC, Rockville, Maryland, USA. ^[6] Microbiotix, Inc., Worcester, Massachusetts, USA. ^[7] Alexandria Center for Life Sciences (West Tower), New York University Langone Medical Center, New York, New York, USA. ^[8]

关键词 MBX-400 filociclovir pharmacokinetics safety