Triazole-Pyridine Dicarbonitrile Targets Phosphodiesterase 4 to Induce Cytotoxicity in Lung Carcinoma Cells.

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作者： Hosadurga K,Keerthy ^[1] ; Surender,Mohan ^[2] ; Basappa ^[3] ; Hanumantharayappa,Bharathkumar ^[4] ; Shobith,Rangappa ^[5] ; Fredrick,Svensson ^[4] ; Andreas,Bender ^[6] ; Chakrabhavi Dhananjaya,Mohan ^[2] ; Kanchugarakoppal S,Rangappa ^[2] ; Rakesh,Bhatnagar ^[7]

作者单位： Department of Chemistry, Center for Post Graduate Studies and Research, St. Agnes College, Bendur, Mangalore, 575002, India. ^[1] Center for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, United Kingdom. ^[2] Laboratory of Molecular Biology and Genetic Engineering, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India. ^[3] Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Central College campus, Palace Road, Bangalore, 560001, India. ^[4] Laboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India. ^[5] Adichunchanagiri Institute for Molecular Medicine, BG Nagara, 571448, Nagamangala Taluk, Mandya District, India. ^[6] Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore, 570006, India. ^[7] Institution of Excellence, Vijnana Bhavan, University of Mysore, Manasagangotri, Mysore, 570006, India. ^[8]

关键词 chemotherapy cytotoxic phosphodiesterase 4 synthetic small molecule