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首页> Journal of medicinal chemistry> Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines.

Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines.

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作者： Carmen,Cerchia ^[1] ; Rosarita,Nasso ^[2] ; Matteo,Mori ^[3] ; Stefania,Villa ^[4] ; Arianna,Gelain ^[4] ; Alessandra,Capasso ^[4] ; Federica,Aliotta ^[2] ; Martina,Simonetti ^[2] ; Rosario,Rullo ^[2] ; Mariorosario,Masullo ^[2] ; Emmanuele,De Vendittis ^[5] ; Maria Rosaria,Ruocco ^[3] ; Antonio,Lavecchia ^[2]

作者单位： Department of Pharmacy, "Drug Discovery" Laboratory , University of Naples Federico II , Via D. Montesano, 49 , 80131 Naples , Italy. ^[1] Department of Molecular Medicine and Medical Biotechnology , University of Naples Federico II , Via S. Pansini 5 , 80131 Naples , Italy. ^[2] Department of Movement Sciences and Wellness , University of Naples "Parthenope" , 80133 Naples , Italy. ^[3] Department of Pharmaceutical Sciences , University of Milan , Via Mangiagalli, 25 , 20133 Milan , Italy. ^[4] Institute for the Animal Production Systems in the Mediterranean Environment , Via Argine 1085 , 80147 Naples , Italy. ^[5]

主题词苯胺化合物(Aniline Compounds);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);药物设计(Drug Design);药物发现(Drug Discovery);酶抑制剂(Enzyme Inhibitors);人类(Humans);酮类(Ketones);黑色素瘤(Melanoma);蛋白质结构, 三级(Protein Structure, Tertiary);治疗结果(Treatment Outcome);cdc25磷酸酶类(cdc25 Phosphatases)

DOI 10.1021/acs.jmedchem.9b00632

PMID 31294975

发布时间 2020-06-10

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Journal of medicinal chemistry

Journal of medicinal chemistry

2019年62卷15期

7089-7110页

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