Over-expression of miR-34a induces rapid cognitive impairment and Alzheimer's disease-like pathology.

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第一作者： S,Sarkar

第一单位： Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, United States; Center for Basic and Translational Stroke Research, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, United States.

作者： S,Sarkar ^[1] ; E B,Engler-Chiurazzi ^[1] ; J Z,Cavendish ^[1] ; J M,Povroznik ^[1] ; A E,Russell ^[1] ; D D,Quintana ^[1] ; P H,Mathers ^[2] ; J W,Simpkins ^[3]

作者单位： Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, United States; Center for Basic and Translational Stroke Research, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, United States. ^[1] Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, United States; Department of Biochemistry, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, United States. ^[2] Department of Physiology & Pharmacology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, United States; Center for Basic and Translational Stroke Research, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, United States. Electronic address: jwsimpkins@hsc.wvu.edu. ^[3]

关键词 ADAM10 Late-onset Alzheimer’s disease Memory-related behaviors NMDAR 2B SIRT1 Tau phosphorylation miR-34a microRNA β amyloid