FXR modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis.

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第一作者： Marcel,Sorribas

第一单位： Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland.

作者： Marcel,Sorribas ^[1] ; Manuel O,Jakob ^[2] ; Bahtiyar,Yilmaz ^[1] ; Hai,Li ^[1] ; David,Stutz ^[2] ; Yannik,Noser ^[2] ; Andrea,de Gottardi ^[2] ; Sheida,Moghadamrad ^[1] ; Moshin,Hassan ^[1] ; Agustin,Albillos ^[3] ; Ruben,Francés ^[4] ; Oriol,Juanola ^[4] ; Ilaria,Spadoni ^[5] ; Maria,Rescigno ^[6] ; Reiner,Wiest ^[7]

作者单位： Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland. ^[1] Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland. ^[2] Department of Gastroenterology, Hospital Universitario Ramón y Cajal, IRYCIS, University of Alcalá, CIBEREHD, Madrid, Spain. ^[3] Hepatic and Intestinal Immunobiology Group, Universidad Miguel Hernández-CIBERehd, San Juan, Spain. ^[4] Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini, 20090 Pieve Emanuele, MI, Italy. ^[5] Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini, 20090 Pieve Emanuele, MI, Italy; Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, MI, Italy. ^[6] Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland; Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address: Reiner.wiest@insel.ch. ^[7]

关键词 FXR Gut-liver axis Gut-vascular barrier Intestinal permeability Liver cirrhosis Mucus Portal hypertension