Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second-Generation Amyloid-β Mouse Model.

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作者： Christian,Sacher ^[1] ; Tanja,Blume ^[1] ; Leonie,Beyer ^[2] ; Finn,Peters ^[1] ; Florian,Eckenweber ^[2] ; Carmelo,Sgobio ^[1] ; Maximilian,Deussing ^[2] ; Nathalie L,Albert ^[1] ; Marcus,Unterrainer ^[1] ; Simon,Lindner ^[1] ; Franz-Josef,Gildehaus ^[1] ; Barbara,von Ungern-Sternberg ^[1] ; Irena,Brzak ^[1] ; Ulf,Neumann ^[3] ; Takashi,Saito ^[3] ; Takaomi C,Saido ^[4] ; Peter,Bartenstein ^[4] ; Axel,Rominger ^[1] ; Jochen,Herms ^[1] ; Matthias,Brendel ^[5]

作者单位： Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich Germany. ^[1] DZNE-German Center for Neurodegenerative Diseases, Munich, Germany. ^[2] Neuroscience, Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland. ^[3] Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan. ^[4] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. ^[5] Department of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland; and. ^[6] Center of Neuropathology and Prion Research, University of Munich, Munich, Germany. ^[7] Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich Germany matthias.brendel@med.uni-muenchen.de. ^[8]

关键词 Alzheimer disease AppNL-G-F microglia spatial learning β-amyloid