Arylsulfatase A, a genetic modifier of Parkinson's disease, is an α-synuclein chaperone.

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第一作者： Jun Sung,Lee

第一单位： Department of Biomedical Sciences, Neuroscience Research Institute, and Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.

作者： Jun Sung,Lee ^[1] ; Kazuaki,Kanai ^[2] ; Mari,Suzuki ^[3] ; Woojin S,Kim ^[4] ; Han Soo,Yoo ^[5] ; YuHong,Fu ^[6] ; Dong-Kyu,Kim ^[5] ; Byung Chul,Jung ^[1] ; Minsun,Choi ^[1] ; Kyu Won,Oh ^[1] ; Yuanzhe,Li ^[1] ; Mitsuyoshi,Nakatani ^[2] ; Tomoko,Nakazato ^[2] ; Satoko,Sekimoto ^[2] ; Manabu,Funayama ^[2] ; Hiroyo,Yoshino ^[2] ; Shin-Ichiro,Kubo ^[2] ; Kenya,Nishioka ^[2] ; Ryusuke,Sakai ^[2] ; Morio,Ueyama ^[4] ; Hideki,Mochizuki ^[7] ; He-Jin,Lee ^[4] ; Sergio Pablo,Sardi ^[7] ; Glenda M,Halliday ^[8] ; Yoshitaka,Nagai ^[9] ; Phil Hyu,Lee ^[5] ; Nobutaka,Hattori ^[4] ; Seung-Jae,Lee ^[7]

作者单位： Department of Biomedical Sciences, Neuroscience Research Institute, and Department of Medicine, Seoul National University College of Medicine, Seoul, Korea. ^[1] Department of Neurology, Juntendo University, School of Medicine, Tokyo 113-8421, Japan. ^[2] Diabetic Neuropathy Project, Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan. ^[3] Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. ^[4] Brain and Mind Centre, Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia. ^[5] Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. ^[6] Department of Neurology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. ^[7] Departmen of Anatomy, School of Medicine, Konkuk University, Seoul, Korea. ^[8] Genzyme, a Sanofi Company, Framingham, Massachusetts, USA. ^[9]

关键词 Parkinson’s disease arylsulfatase A molecular chaperone protein aggregation and propagation α-synuclein