Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.

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作者： Ping,Gao ^[1] ; Xiqiang,Cheng ^[1] ; Lin,Sun ^[1] ; Shu,Song ^[1] ; Mar,Álvarez ^[2] ; Joanna,Luczkowiak ^[2] ; Christophe,Pannecouque ^[3] ; Erik,De Clercq ^[3] ; Luis,Menéndez-Arias ^[4] ; Peng,Zhan ^[5] ; Xinyong,Liu ^[6]

作者单位： Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China. ^[1] Centro de Biología Molecular "Severo Ochoa" (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Madrid, Spain. ^[2] Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. ^[3] Centro de Biología Molecular "Severo Ochoa" (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Madrid, Spain. Electronic address: lmenendez@cbm.csic.es. ^[4] Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China. Electronic address: zhanpeng1982@sdu.edu.cn. ^[5] Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China. Electronic address: xinyongl@sdu.edu.cn. ^[6]

关键词 Dual inhibitors HIV-1 Integrase RNase H