Safety and efficacy of focused ultrasound induced blood-brain barrier opening, an integrative review of animal and human studies.

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第一作者： Ying,Meng

第一单位： Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

作者： Ying,Meng ^[1] ; Christopher B,Pople ^[2] ; Harriet,Lea-Banks ^[2] ; Agessandro,Abrahao ^[3] ; Benjamin,Davidson ^[1] ; Suganth,Suppiah ^[4] ; Laura M,Vecchio ^[2] ; Nardin,Samuel ^[4] ; Faiza,Mahmud ^[2] ; Kullervo,Hynynen ^[5] ; Clement,Hamani ^[6] ; Nir,Lipsman ^[7]

作者单位： Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada. ^[1] Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada. ^[2] Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Canada. ^[3] Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada. ^[4] Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada. ^[5] Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Hurvitz Brain Sciences Research Program, Harquail Centre for Neuromodulation, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada. ^[6] Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Hurvitz Brain Sciences Research Program, Harquail Centre for Neuromodulation, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada. Electronic address: nir.lipsman@sunnybrook.ca. ^[7]

关键词 Blood-brain barrier Drug delivery Focused ultrasound